This retro horror-themed slot from Play’n Go is a rendition of the beloved Gothic horror novel, Strange Case of Dr Jekyll and Mr Hyde, written by Robert Louis Stevenson and published in 1886. The story explores the sides of Dr Henry Jekyll and a mysterious criminal, Edward Hyde.
This title is one of the first online slots published by Play’n Go in 2025. It has a few different features which can seem confusing at first, which is why each one will have a dedicated section in the Potion of Madness gameplay features section later on in this guide.
Potion of Madness slot overview
The Potion of Madness online slot is a wonderful experience, with this starting as soon as you open up the game. As the game loads, you’re greeted with nostalgic comic pages that take you through the story of Dr Jekyll as he transforms into Mr Hyde. This introduction is a nice way to immersive the player into the narrative, especially if they’re not familiar with the classic novel.
The symbols are incredibly high-quality. Not only are they well-drawn, but the colors are eye-catching without being too garish. The shapes are distinct from one another, which is important considering that not everyone might know what each of the apparatus does! Speaking of which, the symbols are Dr Jekyll, Mr Hyde, Transformation Potions, Alchemy Set, Microscope, Stopwatch and a Newspaper. The lowest-paying symbols are your standard 10, Jack, Queen, King and Ace symbols - however, they’re stylised so as not to draw attention away from the main symbols, like we’ve seen in other popular US online slots.
There are a few different gameplay features utilized by Potion of Madness, most of which revolve around how many Transformation Potions land on the reels. However, despite the studio’s long history and impressive catalogue of games, they haven’t made this feature particularly easy to understand as you play the game.
Potion of Madness slot pay table
If your stake is $1, then the following will pay out:
| Symbols | 5x matched | 4x matched | 3x matched |
| Mr Hyde | $45 | $9 | $4.50 |
| Dr Jekyll | $15 | $7.50 | $3.75 |
| Alchemist set | $9 | $4.50 | $2.25 |
| Microscope | $9 | $4.50 | $2.25 |
| Stopwatch | $6 | $3.75 | $1.50 |
| Newspaper | $6 | $3.75 | $1.50 |
| Ace | $5.25 | $3 | $0.75 |
| King | $5.25 | $3 | $0.75 |
| Queen | $4.50 | $2.25 | $0.75 |
| Jack | $4.50 | $2.25 | $0.75 |
| 10 | $3 | $1.50 | $0.75 |
Who made the Potion of Madness slot game?
The Potion of Madness slot game was created by the team at Play’n Go, one of the biggest studios when it comes to slot providers. This studio is behind some of the most popular online slots, including Book of Dead, Legacy of Dead, Rise of Olympus, Reactoonz and Fire Joker.
Founded in 2005, this makes Play’n Go one of the most experienced slot providers in the industry with two decades of operations behind them. It’s no wonder, then, that this company releases titles which are regularly in the top ten of slot leaderboards.
Play’n Go eventually entered North America in 2022, launching in Michigan after obtaining its licence. Since then, the studio has expanded into several different states and partnered with many operators to deliver its games to US fans across the country. If you want to check out Potion of Madness, or any other award-winning Play’n Go slot, then BetMGM, Caesars, BetRivers or Borgata Online are good places to start.
Pros and Cons of Potion of Madness
+ The artwork is modern, crisp and bright
+ Simple gameplay makes for an experience that’s easy to understand
+ Wilds can be sticky, expanding and landing just one can trigger a feature
- There aren’t as many features as you’d expect in this online slot game
- The game has a great theme and concept which doesn’t feel fully realized
Potion of Madness slot table
RTP | 96.2% (RTP ranges) |
Volatility | Medium |
Reels | 5 |
Rows | 3-6 |
Paylines | 10-40 |
Studio | Play’n Go |
Theme | Horror |
Free Spins | Yes |
Bonus games | Yes |
Min bet | $0.10 |
Max bet | $100 |
Max win | 6,000x |
Potion of Madness slot features
The gameplay in Potion of Madness revolves around how many potions land on the reels. Some of these will trigger multiple things happening at once, or nothing at all, so pay attention as we explain how these Potions work before you devolve into Madness.
One Transformation Potion: If just one Transformation Potion lands on the reels, then these will turn any Dr Jeykll symbols into Mr Hydes - which act as Wilds! This is accompanied by a nice little animation so you get to see the ‘process’ of the good doctor being turned into the evil, murderous villain. However, and quite confusingly, there’s still half an animation even these Wilds won’t be part of any winning combinations, which seems more like a waste of time than anything.
Two Transformation Potions: If two Potions land on the reels, then they’ll turn any Dr Jekyll symbols into Mr Hydes, but then these will become sticky for the respins! For each win, the reels will continue respinning and for the duration of the feature, any other Hyde symbols will join the others in being sticky.
Three Transformation Potions: If three Potions land on the reels, then you unlock the ultimate feature at this online slot. You’ll be awarded five free spins, expanded reels, expanding wilds and respins. The Hyde Wild symbols will be sticky between each winning respin, but not between each free spin.
Does the Potion of Madness slot game offer free spins?
When you land three Transformation Potions on the reels, you’ll trigger the Potion of Madness mini-game that starts with five free spins. However, you’re likely to get many more free spins at the online slot than that, because every time you hit a winning payline, you’ll get a re-spin - which doesn’t detract from your amount of free spins! As long as you keep hitting those winning combinations, those free spins will keep going!
Potion of Madness slot conclusion
Potion of Madness is a simple online slot. While it’s very charming (and incredibly well made), it does lean a little too heavily on the feature that requires three Transformation Potions to land on the reels.
In between this feature, there isn’t an awful lot going on and this might feel too slow for any modern slot fans who are used to high-impact, high-intensity slots.
That being said, the sound design in this slot is honestly one of the best we’ve come across. It’s an absolute delight to experience and it’s clear that the team behind this slot have put a lot of love into this title.
While it can be dangerous to reduce games with horror features to being Halloween-themed, we can’t help but wonder whether this slot would’ve been a bigger hit if it was released during October? Sure, it’s polished enough to be a success all-year round, but this slot would’ve easily been one of the best Halloween slots to be released in 2024 and it could’ve gained a lot of traction with that first jump in exposure.
Overall, it might be best to try out Potion of Madness in a free demo mode, which would mean that you can play this online slot for free. That way, you can see whether you get on with the pacing and features Play’n Go have selected for this title.
